Pain and Endometriosis: Understanding the Mechanisms
The pain associated with endometriosis is a central and complex symptom, influenced by
biological, neurological and psychological mechanisms. Here are the main factors involved
in this chronic pain.
Inflammatory mechanisms
- Inflammation: Inflammatory mediators (cytokines, prostaglandins) stimulate
sensory neurons, increasing pain perception. - Neuroangiogenesis: Inflammation promotes the growth of new blood vessels
and nerve fibers in endometriotic tissue, contributing to increased pain.
Nervous Awareness
- Peripheral and central sensitization: nerves close to endometriotic lesions
are sensitized by inflammation, intensifying pain. - Nerve fiber growth: nerve fibers in ectopic tissue can
affect central neuronal activity, exacerbating symptoms.
Psychological Factors and the Central Nervous System
- Stress and psychological distress: Stress often amplifies pain perception and
worsens symptoms. - Interaction with the Autonomic Nervous System: Inflammation and the autonomic
nervous system interact to modulate the pain associated with endometriosis.
Conclusion
Conclusion
Pain in endometriosis results from a complex interaction between inflammation,
nerve sensitization and psychological factors. Understanding these mechanisms is essential for
developing personalized treatments and improving the quality of life of women affected by
this disease.
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